Harald Stenmark: “Mechanisms and importance of lysosome repair”

Damaged lysosomes are harmful to cells and participate in propagation of neurotoxic protein aggregates. Recent studies have shown thatdamaged lysosomes can be repaired by several alternative mechanisms. In our group we have been characterizing lysosome repair mediated by ESCRT proteins and lipids transferred from the endoplasmic reticulum. In my presentation I will discuss our recent findings regarding possible cooperations between these mechanisms and the molecular machinery of lysophagy - autophagic degradation of damaged lysosomes.Speaker Institution: Institute for Cancer Research, Oslo University Hospital, Oslo, Norway